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SR9009 SARM, also known as Stenabolic, has advantages such as greater endurance, improved cardiac function, lower body fat, increased energy levels, and the ability to help preserve lean muscle mass.
Size: 1g | 3g
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SR-9009 Stenabolic is an agonist of the REV-ERB nuclear receptors. It regulates metabolism and circadian behaviour. It has potential use in treating metabolic diseases and sleep disorders. It works by influencing gene expression and enhancing oxidative capacity within skeletal muscle tissue.
SR-9009 is a synthetic compound. It binds to the REV-ERBα/β receptors, which scientists have identified in many parts of the body, including the liver and skeletal muscle system. These receptors regulate the circadian clock, glucose regulation in animal models, and lipid metabolism. Research highlights their critical role as novel metabolic modulators, and investigators in the United States are studying them to understand complex physiological processes. However, the legal status of SR-9009 restricts it strictly to research purposes.
Although SR-9009 is not a SARM (selective androgen receptor modulator), researchers have shown that it binds to REV-ERBα/β. In preclinical models, it produces metabolic and endurance effects that may resemble some outcomes of SARMs. Animal studies demonstrate promising outcomes, but researchers have not conducted human clinical trials on SR-9009. These findings confirm that scientists use it only for laboratory analysis. Researchers do not intend it for human consumption.
Professor Thomas Burris at the Scripps Research Institute originally developed the compound, and his team published foundational work in Nature (2012). Various animal models show that it supports fatty acid oxidation, increases energy expenditure, and stimulates mitochondrial biogenesis. This process helps break down fatty acids, reduces adipose tissue, and replicates some effects of exercise without training, while experimental data even suggest protective effects against myocardial infarction and pressure overload in cardiovascular disease models, though these results are limited to animal studies.
Boosts Muscular Endurance
Fatigue is often a limiting factor for lifters. SR-9009 provides an edge by activating protein pathways. It enhances mitochondrial performance in skeletal muscle. Researchers regard it as an exercise mimetic. It improves both the quality and the number of mitochondria. Asia Research shows that daily doses in lab settings boost endurance. This may suggest potential endurance improvements in preclinical studies. Enhanced physical activity results in more sustained performance gains. It also produces noticeable performance benefits during training in animal models.
Helps With Weight Loss
SR-9009 has shown potential to maintain elevated metabolism. This is a major factor in fat loss and muscle support. By increasing mitochondrial density, it supports greater medical use potential in the future. Asia Preclinical results indicate it aids fat oxidation. It improves fat metabolism and maximizes energy output. This makes it attractive in animal endurance research. They require fuel efficiency for longer periods of exercise.
If glucose metabolism is regulated, insulin levels also remain stable. Improved insulin sensitivity may enhance nutrient uptake into tissue. While no human clinical trials have been conducted, findings from pre-clinical models suggest it may influence the central nervous system. When paired with a caloric deficit in experimental settings, it may optimize body composition and athletic performance.
Perfect for Building Muscle
SR-9009 enables Asia researchers to explore how increased energy availability affects tissue growth. Its pivotal role in metabolic regulation boosts insulin sensitivity. It strengthens exercise capacity. This supports higher energy metabolism. These effects are often sought from anabolic steroids. By activating specific metabolic pathways, SR-9009 improves mitochondrial function. It also enhances mitochondrial activity. This leads to measurable changes in lean mass during preclinical protocols, though human data is not available.
Boosts Muscular Strength
Preclinical studies on similar compounds point toward improved metabolic rate and recovery benefits. Studies in heart failure and cardiovascular disease models demonstrate reductions in fat mass. They also show improved tolerance of metabolic stress and more stable transcription factors linked to muscle growth. By supporting metabolic processes, SR-9009 may also aid heart health. It may enable faster recovery after laboratory test sessions. Some investigators note enhanced performance during longer periods of training simulation. This reflects increased basal metabolic rate. However, its safety profile in humans has not been established. At high doses, potential side effects and off-target actions need more study.
Unlike traditional anabolic compounds, SR-9009 does not suppress testosterone and does not directly impact androgen receptors, so post cycle therapy is generally not considered necessary when the compound is studied alone, though stacking with other compounds may change that requirement.
In all cases, SR-9009 remains restricted to research purposes only, and when combined with proper nutrition in controlled experiments, it continues to provide insight into metabolic pathways, endurance outcomes, and aspects of glucose metabolism.
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[1] Shen W, Zhang W, Ye W, Wang H, et al. SR 9009 induces a REV-ERB dependent anti-small-cell lung cancer effect through inhibition of autophagy. Theranostics. 2020 Mar 15;10(10):4466-4480.
[2] Geldof L, Deventer K, Roels K, Tudela E, Van Eeno P. In Vitro Metabolic Studies of REV-ERB Agonists SR9009 and SR9011. Int J Mol Sci. 2016 Oct 3;17(10):1676.
[3] Saiz N, Herrera-Castillo L, Isorna E, Delgado MJ, et al. REV-ERBα Agonist SR 9009 Promotes a Negative Energy Balance in Goldfish. Int J Mol Sci. 2022 Mar 8;23(6):2921.
[4] Dierickx P, Emmett MJ, Jiang C, Uehara K, et al. SR 9009 has REV-ERB-independent effects on cell proliferation and metabolism. Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12147-12152.
[5] Solt LA, Wang Y, Banerjee S, Hughes T, et al. Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature. 2012 Mar 29;485(7396):62-8.
Molecular Formula: C20H24ClN3O4S
Molecular Weight: 437.94026 g/mol
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DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Asia Direct Sarms website is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.
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