Tesofensine, also known as TE, is a novel triple monoamine reuptake inhibitor primarily studied for obesity and weight control. By inhibiting dopamine, norepinephrine, and serotonin reuptake, TE affects appetite and energy metabolism, aiding in weight loss and improved body composition. It is for research only and not approved for human use outside controlled trials. For those in research seeking to buy Tesofensine, ensure that all regulatory and safety guidelines are strictly followed.
Tesofensine is a pharmacological compound classified as a new serotonin, norepinephrine, and dopamine reuptake inhibitor. It functions by blocking the reuptake of the three monoaminergic neurotransmitters dopamine, norepinephrine, and serotonin. This action results in elevated levels of these neurotransmitters in the brain, affecting mood, appetite, and energy metabolism.
Initially investigated for the treatment of Parkinson’s and Alzheimer’s diseases due to its indirect enhancement of cholinergic neurotransmission, Asia research shifted focus due to its significant impact on weight loss. TE has demonstrated potential in reducing body weight through decreased appetite and increased energy expenditure. However, it remains under investigation and is designated solely for use in clinical research settings, with no approval for broad human use.
Tesofensine operates by simultaneously inhibiting the reuptake of three key monoamine neurotransmitters: dopamine, norepinephrine, and serotonin. This mechanism results in higher concentrations of these neurotransmitters in the synaptic cleft, leading to prolonged and enhanced neurotransmitter activity. The increase in dopamine levels contributes to improved mood and reward-related behaviors, which can reduce the dependence on food as a source of pleasure. Elevated norepinephrine levels enhance arousal and energy expenditure, thereby increasing calorie burn. Increased serotonin levels are known to induce satiety and diminish appetite, further aiding in weight reduction. The combined effect of these actions leads to a significant decrease in appetite and an increase in energy metabolism, promoting weight loss and an improved body composition. Tesofensine’s intricate mode of action provides a multi-faceted approach to managing weight and treating conditions with an underlying neurological component.
Molecular Formula: C17H23Cl2NO
Molecular Weight:
328.3 g/mol
PubChem CID: 11370864
Source: PubChem
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Buy Tesofensine Capsules online for Asia research purposes and enjoy the convenience of direct delivery, ensuring your research activities continue without interruption.
Is Tesofensine safe?
Clinical trials have demonstrated that TE is generally well-tolerated, but like all medications, it may have side effects. Common side effects include dry mouth, insomnia, and increased heart rate. It is crucial to follow Asia medical guidance and undergo regular monitoring while using Tesofensine.
Is Tesofensine legal?
The legality of Tesofensine varies by country and its pharmaceutical regulations. In some places, it may be approved for specific medical use, while in others, it remains under investigation.
The FDA in the U.S. has not approved Tesofensine for public use, and its legal status is still under review. Similarly, the Therapeutic Goods Administration (TGA) in Australia and the Medicines and Healthcare products Regulatory Agency (MHRA) in the UK have not given approval for its use outside clinical settings.
Consult Asia local regulatory authorities to understand its legal status in your area. It’s also important to buy Tesofensine from reputable sources and follow local legal guidelines to ensure safety and compliance.
Can Tesofensine cause anxiety?
While Tesofensine shows promise for weight loss, researchers must be aware of possible side effects like anxiety. Some subjects may experience increased anxiety due to the drug’s impact on neurotransmitters like dopamine, noradrenaline, and serotonin, which regulate mood.
This anxiety can manifest as nervousness, restlessness, or even panic attacks. It’s crucial for researchers to monitor their subjects mental health and report any new or worsening symptoms to medical professionals. Proactive management with professional guidance can help mitigate risks and ensure safer treatment.
Does Tesofensine work?
Tesofensine has shown considerable promise in Asia clinical trials for its effectiveness in aiding weight loss. Studies indicate that Tesofensine can significantly reduce body weight in overweight and obese individuals when used alongside a balanced diet and regular exercise.
By inhibiting the reuptake of dopamine, noradrenaline, and serotonin, it facilitates sustained appetite suppression and increased energy expenditure. While individual results can vary, the evidence suggests that many trial subjects experience noticeable weight loss.
For further insights, check out the latest blog posts on Tesofensine.
[1] M.H.Larsen, H.Rosenbrock, F.Sams-Dodd, and J.D.Mikkelsen “Expression of brain derived neurotrophic factor, activity-regulated cytoskeleton protein mRNA, and enhancement of adult hippocampal neurogenesis in rats after sub-chronic and chronic treatment with the triple monoamine re-uptake inhibitor tesofensine”. European Journal of Pharmacology, 2007 Jan 26;555(2-3):115-21.
[2] A.Astrup, D.H.Meier, B.O.Mikkelsen, et al “Weight loss produced by tesofensine in patients with Parkinson’s or Alzheimer’s disease”. Obesity, Silver Spring Md, vol. 16, no. 6, pp. 1363–1369, Jun. 2008.
[3] A.Astrup, S.Madsbad, L.Breum et al “Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: a randomised, double-blind, placebo-controlled trial”. The Lancet, 2008 Nov 29;372(9653):1906-1913.
[4] J.A.Gilbert, C.Gasteyger, A.Raben, et al “The effect of tesofensine on appetite sensations”. Obesity, Silver Spring Md volume 20, no. 3, pp. 553–561, Mar. 2012.
[5] A.M.D.Axel, J.D.Mikkelsen, and H.H.Hansen “Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of alpha1 adrenoceptor and dopamine D1 receptor pathways in the diet-induced obese rat”. Neuropsychopharmacology, 2010 Jun;35(7):1464-76.
[6] B.M.Yung Cheung, T.Tsang Cheung, N.R.Samaranayake “Safety of antiobesity drugs”. Therapeutic Advances in Drug Safety, 2013 Aug 4, (4):171-81.
[7] A.Sjödin, C.Gasteyger, A.Lh.Nielsenet et al “The effect of the triple monoamine reuptake inhibitor tesofensine on energy metabolism and appetite in overweight and moderately obese men”. International Journal of Obesity, volume 34, no. 11, pp. 1634–1643, Nov. 2010.
[8] L.Appel, M.Bergström, J.B.Lassen, and B.Långström “Tesofensine, a novel triple monoamine re-uptake inhibitor with anti-obesity effects: Dopamine transporter occupancy as measured by PET”. European Neuropsychopharmacology, Volume 24, Issue 2, February 2014, Pages 251-261.
[9] AB.Saniona “Saniona’s tesofensine meets primary and secondary endpoints in Phase 3 obesity registration trial”. Press Releases from GlobeNewswire News Room, Dec. 17, 2018.
[10] D.M.Marks, C.U.Pae, and A.A.Patkar “Triple Reuptake Inhibitors: The Next Generation of Antidepressants”. Current Neuropharmacology, 2008 Dec; 6(4): 338–343.
[11] Ł.R.Drzyzga, A.Marcinowska, and E.Obuchowicz “Antiapoptotic and neurotrophic effects of antidepressants: a review of clinical and experimental studies”. Brain Research Bulletin, Volume 79, Issue 5, 30 June 2009, Pages 248-257.
[12] S.M.Korte, J.Prins, A.M.Krajnc et al “The many different faces of major depression: it is time for personalized medicine”. European Journal of Pharmacology, 2015 Apr 15:753:88-104.
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